Author contributions: V. All authors discussed the results and commented on the manuscript. Table S2. Arm-specific markers of adherence and changes in risk factors, including arm 1 after crossover to FMD, and summary of FMD arms 1 and 2. Table S4. Changes in risk factors and metabolic markers of adherence 3 months after intervention. Calorie restriction or changes in dietary composition can enhance healthy aging, but the inability of most subjects to adhere to chronic and extreme diets, as well as potentially adverse effects, limits their application. We compared subjects who followed 3 months of an unrestricted diet to subjects who consumed the FMD for 5 consecutive days per month for 3 months. Three FMD cycles reduced body weight, trunk, and total body fat; lowered blood pressure; and decreased insulin-like growth factor 1 IGF No serious adverse effects were reported. After 3 months, control diet subjects were crossed over to the FMD program, resulting in a total of 71 subjects completing three FMD cycles.
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