Parlevliet, J. Willems van Dijk, J. Romijn, H. High fat feeding induces a variety of obese and lean phenotypes in inbred rodents. We hypothesized that this differing dopaminergic tone contributes to the distinct metabolic profiles of these animals. Haloperidol treatment reduced the voluntary activity and energy expenditure of DR mice and induced insulin resistance in these mice. Conversely, bromocriptine treatment tended to reduce bodyweight and voluntary activity, and reinforce insulin action in DIO mice. These results show that DRD2 activation partly redirects high fat diet induced metabolic anomalies in obesity-prone mice. Conversely, blocking DRD2 induces an adverse metabolic profile in mice that are inherently resistant to the deleterious effects of high fat food. Dopamine is intimately involved in the regulation of energy balance.
Thank you for visiting nature. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In , Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D 2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research. Hoebel, B. Kelley, A. Volkow, N. Avena, N. Johnson, P. Wang, G. Lancet , — Stice, E.
Am J Clin Nutr ; 91 dopamine — Figure 3. Fat, and D. Jong, V. Jackson J. Hyperinsulinemic euglycemic clamp studies started at diet and were performed as described earlier [ 26 ]. Receptor, J. In high, blocking dopaminergic transmission by means of haloperidol induces insulin resistance of glucose metabolism in DR mice.